now there's a title that catches the eye.
paper's based on ESMfold predictions. it's an intriguing idea, but i fear the results may be an artifact of the training data. they may be seeing poor generalization of ESM rather than a biological signal
not very easy to experimentally verify. could be interesting to explore orthogonal protein DL models to explore the effect of model selection. that wouldn't solve the problem of training on natural proteins then comparing against random and designed sequences
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