Interesting study. Always a bit tricky to extrapolate mechanisms from these blood biomarker studies, but would be interesting if the soluble receptors found really are shedding. Wonder why that would happen though and if malaria-specific.
Gabriele Pollara
@gpollara.bsky.social
9266 Followers
1533 Following
Infectious Diseases doctor (at UCLH) and academic (at UCL). Research focuses on immune responses to TB and leprosy, but I'm also involved in too many other projects I probably shouldn't be...
-
-
'The prominence of soluble receptors such as IL-2RA & TNFRSF1B in the severity-associated signature suggests a dynamic regulation of immune signaling during acute infection. This (...) highlights the importance of receptor shedding as a potential biomarker of immune activation' #Immunology #Malaria
Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity
While the immune response to Plasmodium falciparum malaria has been studied extensively, the circulating proteome and its cellular origins remain poorly characterized. Lautenbach et al. address this b...
-
Hope good Turkish coffee!
How long is the journey?
-
Slop?
-
Bye, data centre. Hello, cloud. Crossref's main systems are now in the cloud—processing jobs in seconds instead of hours, cutting long queues, and improving disaster recovery. Read about the move, the challenges, and what's next: https://doi.org/10.64000/wd6rx-vpq73 #OpenInfrastucture #DataCentre
-
War: good for bacteria, bad for infection control
Multidrug-resistant bacteria amid health-system collapse in Gaza
Gaza's health-care system has faced widespread destruction during the ongoing Israeli military invasion that began in October, 2023, leading to a proliferation of disease outbreaks.1,2 During this tim...
-
V good summary 😔
-
Generative AI framework invents 2 new potential antibiotics that could kill drug-resistant gonorrhoea & MRSA. 🧪💊🦠
"While AI promises to dramatically improve drug discovery & development, we still need to do the hard yards when it comes to testing safety and efficacy." www.bbc.co.uk/news/article...
AI designs new superbug-killing antibiotics for gonorrhoea and MRSA
Two new potential drugs have been designed by AI to kill drug-resistant bacteria, in a major Massachusetts Institute of Technology study.
-
Link to new study in Cell (sadly not open access 😞):
A generative deep learning approach to de novo antibiotic design 🧪💊🦠 www.cell.com/cell/abstrac...
A generative deep learning approach to de novo antibiotic design
A generative AI platform is developed for de novo antibiotic design, yielding lead compounds with selective antibacterial activity, distinct mechanisms of action, and in vivo efficacy against multidru...
-
Wow!!!!
