definitely a fascinating question. we haven't gotten there yet, even for the motor system, but i think we now have the tools to ask it. (btw, this is tony's project, if you get a chance to chat w him about it).
John Tuthill
@tuthill.bsky.social
1981 Followers
329 Following
Neuroscientist at UW studying proprioception and motor control. Promoting the people and work in my lab (www.tuthill.casa). Also pursuing a snow fly side habit (www.snowflyproject.org).
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Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8
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https://www.jstor.org/stable/pdf/57058.pdf
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i think it is clear that insect (and other animal) brains are evolutionarily specialized for controlling specific bodies to a very large extent. in the fly, what motor plasticity is present helps to compensate for asymmetries in the body, eg from development or injury, by adjusting feedback gains.
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agree w davi. we can operantly condition an adult fly to control a cursor with motor neuron firing rates (paper in prep), but a fly is not going to reach an equivalent level of dexterity with totally new effectors. might be more plastic if you could hook it up during metamorphosis.
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bon voyage to grant chou who, after 3 years in our lab, is now extremely well calibrated and starting his phd @princetonneuro.bsky.social this week.
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It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!)
thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
Synaptic connectomics: status and prospects — a Comment article by Davi D. Bock
#neuroscience #neuroskyence
Synaptic connectomics: status and prospects - Nature Reviews Neuroscience
High-throughput volume electron microscopy and deep learning-driven automated segmentation have revolutionized the mapping of neural circuits at the level of individual neurons and synapses, revealing...
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Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines. tryptyr.myalcon.com?gad_source=1...
TRYPTYR (acoltremon ophthalmic solution) 0.003% eye drops | Alcon US
TRYPTYR is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease. See prescribing information, how to save, and more.
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Total disaster for the #drosophila community if flybase disappears
News via The Transmitter www.thetransmitter.org/community/ha...
Harvard University lays off fly database team
The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.
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congratulations to our own Juan Ispizua on being selected as a pew latin american postdoctoral fellow
Pew Latin American Fellows
The Pew Latin American Fellows Program in the Biomedical Sciences provides support for young scientists from Latin America to receive postdoctoral training in the United States. The program gives thes...
