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Fly Neuroscientist and other good things.
We integrated our atlas with the connectome using shared features, such as lineage, segment, molecular info (i.e. neurotransmitter, Notch) and neurogenesis timing. We mapped 122 transcriptional pools, each one containing an average of 26 anatomically defined neuron types. 4/8
With this atlas in place, we mapped sex differences in the atlas and adult connectomes, identifying female-specific apoptosis and transcriptional divergence as drivers of sexually dimorphic development. 7/8
Thanks to all authors and support from #MRC_LMB, @neurohub-cnr.bsky.social , @camzoology.bsky.social , #flyconnectome, @wellcometrust.bsky.social , @erc.europa.eu, @astra-zeneca.bsky.social and @cruk-ci.bsky.social. FIN
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8
Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!
FlyBase needs your help! Visit the link below for more information, and please consider donating to help save this amazing resource. wiki.flybase.org/wiki/FlyBase...
The #BANC connectome sample was the best dissection of ~150 by @mindyisminsu.bsky.social! Behaviourally characterised by @debivort.bsky.social lab, microCT used to assess integrity before continuing. Then Minsu and @jasper-tms.bsky.social imaged over ~7 months
Details: github.com/jasper-tms/t...
It’s surreal to think that every neuron and synapse in the fly brain + cord that was dissected almost five years ago (the photo’s still on the lab slack!) is now just a click away on Codex codex.flywire.ai?dataset=banc. This wouldn’t have been possible without the incredible team behind it!
It’s surreal to think that every neuron and synapse in the fly brain + cord that was dissected almost five years ago (the photo’s still on the lab slack!) is now just a click away on Codex codex.flywire.ai?dataset=banc. This wouldn’t have been possible without the incredible team behind it!
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
The fly #BANC connectome benefits from specialists’ annotations.
@ellenlesser.bsky.social helped us annotate wing sensory neurons and @tony-azevedo.bsky.social wing + other motor neurons, see them here!: ng.banc.community/2025a/wing-n...
In Codex: codex.flywire.ai/app/search?f...
So happy to share this project detailing fly wing sensory neurons! I started this project just by asking what the axons of the wing chordotonal organ looked like, and I found many other cool structures along the way.
Explore neurons that enter/exit the fly central nervous system by body part with this clickable fly!: codex.flywire.ai/app/body_par...
(graphics: @mottcallie.bsky.social, tool: Arie Matisliah)
Vector graphics! github.com/wilson-lab/s...
Effector cells in 3D! ng.banc.community/2025a/effere...
For the BANC, @jasper-tms.bsky.social and I have added layers for neurons in other datasets to our neuroglancer environment. Search by name and see your favourite neurons in the same space! See an example here: ng.banc.community/2025a/DNa01-...
