Thank you @kaniacz.bsky.social for making such good quality libraries for us! It has been great to coordinate work with you!
Erika Dona
@erikadona.bsky.social
68 Followers
46 Following
Neuroscientist decoding the molecular logic of brain development — mapping how neurons acquire identity, connect into circuits, and diverge between sexes. Researcher Milan at CNR Institute of Neuroscience, Milan
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Thanks to all authors and support from #MRC_LMB, @neurohub-cnr.bsky.social , @camzoology.bsky.social , #flyconnectome, @wellcometrust.bsky.social , @erc.europa.eu, @astra-zeneca.bsky.social and @cruk-ci.bsky.social. FIN
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Amazingly, we found a common transcription factor code across all lineages. Each neuron selects a stable subset of 17 shared TFs based on birth order. This defines a transcriptional ‘timestamp’ that persists into adulthood. The same code is used in the central brain. 6/8
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We integrated our atlas with the connectome using shared features, such as lineage, segment, molecular info (i.e. neurotransmitter, Notch) and neurogenesis timing. We mapped 122 transcriptional pools, each one containing an average of 26 anatomically defined neuron types. 4/8
